EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.28 | LY134046 | selective inhibitor, IC50: 0.0019 mM | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.28 | 9-methylnorharman + S-adenosyl-L-methionine | Homo sapiens | PNMT catalyzes the 2N-methylation of beta-carbolines, forming 2N-methylated beta-carbolinium cations, which are structural and functional analogs of the Parkinsonian-inducing toxin MPP+ | ? + S-adenosyl-L-homocysteine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.28 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.28 | adrenal medulla | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.28 | 9-methylnorharman + S-adenosyl-L-methionine | 2N-methylation | Homo sapiens | ? + S-adenosyl-L-homocysteine | - |
? | |
2.1.1.28 | 9-methylnorharman + S-adenosyl-L-methionine | PNMT catalyzes the 2N-methylation of beta-carbolines, forming 2N-methylated beta-carbolinium cations, which are structural and functional analogs of the Parkinsonian-inducing toxin MPP+ | Homo sapiens | ? + S-adenosyl-L-homocysteine | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.1.1.28 | 0.0019 | - |
selective inhibitor, IC50: 0.0019 mM | Homo sapiens | LY134046 |